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The principal cytochrome P450 isoenzyme included appears to become CYP2E1, with CYP1A2 and CYP3A4 as extra pathways. About 85% of the oral dose seems within the urine within 24 several hours of administration, most given that the glucuronide conjugate, with little quantities of other conjugates and unchanged drug (see OVERDOSAGE) for toxicity infor